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Open WellbeingWhat the studies actually measured

Mood, stress and thinking

Vitamin B6and Depression

Both sources here measured lower depression.

How sure anyone can be

Low certainty, level 2 of 4

Further research is likely to change this.

The most certain of the two findings here; each record carries its own.

The numbers reported

One source’s range, drawn against its own line of no difference and scaled to its own numbers.

0.710.81 risk ratio0.93

This range stays on one side of the no-difference line.

Bar the confidence interval — the range the true effect is likely to sit inNotch the number the source reportedLine where there would be no difference at all

Two sources, newest first

What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. A fixed rule worked this out from the source’s own fields. Nobody checked this rating by hand.

  • Randomised trial, 2026 · 58 participants

    Low certainty, level 2 of 4

    High Dose Vitamin B6 Reduces Depression Symptoms.

    Depress Anxiety. 2026;2026:8926512. doi:10.1155/da/8926512. PMID:42569537.

    Number reported
    0.2
    Which way it went
    Lower
    Likely range
    Not in the abstract
    Source’s own words
    partial eta-squared for DASS depression vs placebo or vitamin B12; positive is the reported selective reduction in the mild or more severe baseline group
    Who was studied
    Mild or more severe depression at baseline
    Compared with
    placebo or vitamin B12
    Amount taken
    100 mg/d vitamin B6 as pyridoxine
    For how long
    30 days
    Disagreement between studies
    Not in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at High, 2 steps down: risk of bias and imprecision
    1. Starts at High
    2. Risk of bias brought it down to Moderatethe abstract reports no risk-of-bias or quality appraisal, so study limitations cannot be ruled outNot in the abstract
    3. Imprecision brought it down to Lowthe abstract reports no confidence interval for the estimateNot in the abstract
    4. Ends at Low2 steps down.
    Checked, nothing to step it down for
    indirectness
    Inconsistency
    One study, so there was nothing to disagree

    Imprecision stops at the first check that applies; others may apply too.

    Source saved; quote checked byte-for-byte against it by software; no signature.

    Read the abstract on PubMed

  • Cohort study, 2022

    Very low certainty, level 1 of 4

    Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis.

    Nutr Rev. 2022;80(3):351-366. doi:10.1093/nutrit/nuab014. PMID:33912967.

    Number reported
    0.81 risk ratio
    Which way it went
    Lower
    Likely range
    0.71 to 0.93
    Source’s own words
    pooled relative risk of depression, highest versus lowest category of dietary vitamin B6 intake
    Who was studied
    Adult
    Compared with
    lowest category of dietary vitamin B6 intake
    Amount taken
    Not in the abstract
    For how long
    Not in the abstract
    Disagreement between studies
    Not in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at Low, 2 steps down: risk of bias and imprecision
    1. Starts at Low
    2. Risk of bias brought it down to Very lowthe abstract reports no risk-of-bias or quality appraisal, so study limitations cannot be ruled outNot in the abstract
    3. Imprecision — already at Very low, the lowest rungthe abstract does not state how many participants were pooledNot in the abstract
    4. Ends at Very low2 steps down.
    Checked, nothing to step it down for
    indirectness
    Inconsistency
    No disagreement reported, and no count of studies behind it

    Imprecision stops at the first check that applies; others may apply too.

    AI-reviewed & signed — an AI agent re-read this finding against the saved source and checked that the quote, the numbers, the units and the direction match it. No person read it. The owner authorised the agent to sign the batch with the owner's key, and every build rechecks that signature against these exact bytes.

    Read the abstract on PubMed

What is still missing from these readings

  • One gives no likely range, so how precise that number is is unknown.
  • One do not say how many people took part.
  • Amount taken — One of Two readings: Not in the abstract.
  • For how long — One of Two readings: Not in the abstract.

Something nobody wrote down is never a zero and never a guess.

Still to read for Vitamin B6

Two of the nine things on our list for Vitamin B6 have no reading here yet:

  • High-sensitivity CRP
  • Interleukin-6

Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.

Read next

This is a library, not advice. No recommendation, no dose, no diagnosis, no ranking. We never ask about your symptoms, and nothing here is tailored to you.