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Open WellbeingWhat the studies actually measured

Blood sugar and insulin

Seleniumand HOMA-IR

Both sources here found no clear difference in HOMA-IR.

How sure anyone can be

Moderate certainty, level 3 of 4

Further research may change this.

The most certain of the two findings here; each record carries its own.

The numbers reported

One source’s range, drawn against its own line of no difference and scaled to its own numbers.

-2.14-0.820.5

This range crosses the no-difference line, so these numbers fit a real difference and no difference at all equally well.

Bar the confidence interval — the range the true effect is likely to sit inNotch the number the source reportedLine where there would be no difference at all

Two sources, newest first

What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. A fixed rule worked this out from the source’s own fields. Nobody checked this rating by hand.

  • Systematic review, 2023

    Moderate certainty, level 3 of 4

    Selenium supplementation effect on glycemic control: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.

    Pharmacol Res. 2023;195:106888. doi:10.1016/j.phrs.2023.106888. PMID:37574154.

    Number reported
    -0.82
    Which way it went
    No clear difference
    Likely range
    -2.14 to 0.5
    Source’s own words
    weighted mean difference in HOMA-IR vs placebo; interval includes no difference
    Who was studied
    Not stated in the abstract
    Compared with
    placebo
    Amount taken
    Not in the abstract
    For how long
    Not in the abstract
    Disagreement between studies
    Not in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at High, one step down: imprecision
    1. Starts at High
    2. Imprecision brought it down to Moderatethe confidence interval includes no effectReported in the abstract
    3. Ends at ModerateOne step down.
    Checked, nothing to step it down for
    risk of bias and indirectness
    Inconsistency
    No disagreement reported, and no count of studies behind it

    Imprecision stops at the first check that applies; others may apply too.

    Source saved; quote checked byte-for-byte against it by software; no signature.

    Read the abstract on PubMed

  • Systematic review, 2022

    Low certainty, level 2 of 4

    Selenium supplementation for polycystic ovary syndrome: a meta-analysis of randomized controlled trials.

    Gynecol Endocrinol. 2022;38(11):928-934. doi:10.1080/09513590.2022.2118709. PMID:36050880.

    Number reported
    -0.51 standardised effect size
    Which way it went
    No clear difference
    Likely range
    -3.79 to 2.77
    Source’s own words
    standardized mean difference in HOMA-IR vs placebo; interval includes no difference
    Who was studied
    Patients with polycystic ovary syndrome
    Compared with
    placebo
    Amount taken
    Not in the abstract
    For how long
    Not in the abstract
    Disagreement between studies
    Not in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at High, 2 steps down: risk of bias and imprecision
    1. Starts at High
    2. Risk of bias brought it down to Moderatethe abstract reports no risk-of-bias or quality appraisal, so study limitations cannot be ruled outNot in the abstract
    3. Imprecision brought it down to Lowthe confidence interval includes no effectReported in the abstract
    4. Ends at Low2 steps down.
    Checked, nothing to step it down for
    indirectness
    Inconsistency
    No disagreement reported, and no count of studies behind it

    Imprecision stops at the first check that applies; others may apply too.

    Source saved; quote checked byte-for-byte against it by software; no signature.

    Read the abstract on PubMed

What is still missing from these readings

  • Two do not say how many people took part.
  • Amount taken — Not in the abstract.
  • For how long — Not in the abstract.

Something nobody wrote down is never a zero and never a guess.

Still to read for Selenium

Nine of the 20 things on our list for Selenium have no reading here yet:

  • Depression
  • Estimated VO2max
  • Free thyroxine (fT4)
  • Free triiodothyronine (fT3)
  • High-sensitivity CRP
  • Mood
  • Oxidative stress (F2-isoprostanes)
  • Plasma Selenium
  • Thyroglobulin Antibodies (TgAb)

Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.

Read next

This is a library, not advice. No recommendation, no dose, no diagnosis, no ranking. We never ask about your symptoms, and nothing here is tailored to you.